Pathogenic Organisms in Varanidae and Their Potential as Zoonotic Diseases

Syaiful Rizal, R A Rahmawati


Monitor lizards have various body sizes, belong to the Varanidae and it is reported that there were various kinds of pathogenic organisms in their bodies. This review aims to describe various information on pathogenic organisms and their potential as zoonotic diseases and can be used as a reference in the prevention of zoonotic diseases originating from Varanidae. The results of this review discuss two types of viruses, three types of bacteria, five types of protozoa, two types of arthropods, and seven types of endoparasites that are pathogenic in Varanidae. Based on this information it is known that potentially zoonotic pathogens include bacteria group is Salmonella spp. and Anaplasma phagocytophilum; groups of protozoa was Giardia spp. and Cryptosporidium sp.; Arthropod group namely Amblyomma sp. which carries the bacteria Rickettsia sp., Borrelia spp. and Anaplasma spp. and the endoparasite group consisting of Ascaris sp., Strongyloides sp., Pentastomida, and Angiostrongylus cantonensis, while for the virus group, there were no pathogenic organisms with zoonotic potential. The extensive use of Varanidae by humans as exotic pets, as well as for consumption and medicine has great potential in the transmission of zoonotic diseases. Those are possible because the varanids non-aseptically environment. The proper handling and maintenance of monitor lizards are necessary to prevent the spread of zoonotic diseases. Unhygienic and less aseptic way of handling food products of animal origin can lead to the potential for transmission of pathogenic organisms (foodborne disease). Efforts to prevent the transmission of foodborne diseases can apply Good Hygienic Practices (GHP) with the process of cooking reptile meat for consumption. Besides, disease transmission can be prevented by implementing the One Health concept.


Varanidae; zoonotic; organism; pathogen; One Health

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Abdel–Aziz A, Abou–Senna FM, Abdel–Gawad MA, El–Nour MFA. 2019. A new species of eimeria (Apicomplexa: Eimeriidae) from the desert monitor, Varanus griseus griseus (Lacertilia: Varanidae). Proceeding the 9th International Conference for Basic Sciences, Energy, Environment and Sustainable Development. Cairo, 27-29 Maret. 2017. Cairo (Egypt): Al-Azhar University.

Agustin ALD, Koesdarto S, Lukiswanto BS, Suwanti LT, Arifin Z, Putranto ED. 2017. Morphological identification nematodes Tanqua tiara found on gastric Varanus salvator at East Java. The Veterinary Medicine International Conference 2017, KnE Life Sciences. Surabaya, 12-14 Juli. 2017. Surabaya (Indonesia): Universitas Airlangga. p. 668–676.

Amelia KA, Ernawati R, Hastutiek P, Yunus M, Setiawan B, Sunarso A. 2020. Identification and ticks infestation pattern on monitor lizard (Varanus salvator, Byers, d. 2000). J Parasite Sci. 4:37-40.

Ariel E. 2011. Viruses in reptiles. Vet Res. 42, art number100.

Arnafia W, Ningrum SG, Adji RS, Lukman DW, Pasaribu FH, Wibawan IWT. 2016. Isolation of Salmonella from reptiles in pet shop and its susceptibility to antibiotics in Indonesia. HVM Bioflux. 8:177-181.

Auliya M, Koch A. 2020. Visual identification guide to the monitor lizard species of the world (genus Varanus). Bonn (Germany): Bundesamt für Naturschutz (BfN).

Ball I. 2015. Tracking adenovirus infections in reptiles [Dissertation]. [Gießen (Germany)]: Justus-Liebig-Universität Gießen.

Barboza T, Beaufrere H. 2018. Epipterygoid bone salmonella abscess in a savannah monitor (Varanus exanthematicus). J Herpetologic Medic Surg. 28:29–33.

Bennett D. 2015. International trade in the blue tree monitor lizard Varanus macraei. Biawak. 9:50-57.

Bhadesiya CM, Patel VA, Gajjar PJ, Anikar, MJ. 2020. First record & clinical management of tick infestation by Amblyomma gervaisi, giardiasis and tail injury in a bengal monitor (Varanus bengalensis; Daudin, 1802) in Himmatnagar, Gujarat (India). Int J Adv Res Biol Sci. 7:71-74.

Biru DMA, Detha AIR, Wuri DA. 2018. Kajian pemahaman peternak dan pelaku usaha produk pangan asal hewan tentang penyakit zoonosis dan pencegahannya di kota Kupang. Jurnal Kajian Veteriner. 6:85-111.

Blake DP. 2015. Eimeria genomics: Where are we now and where are we going?. Vet Parasitol. 212:68–74.

Bzdil J, Holy O, Toporcak J. 2017. Salmonella enterica subspecies enterica serovar paratyphi B as a disease-causing agent in reptiles in the Czech Republic. Veterinarni Medicina. 62:410–415.

Chia M-Y, Jeng C-R, Hsiao S-H, Lee A-H, Chen C-Y, Pang VF. 2009. Entamoeba invadens myositis in a common water monitor lizard (Varanus salvator). Vet Pathol. 46:673-676.

Cho ES, Jung SW, Jung H-D, Lee IY, Yong T-S, Jeong SJ, Kim HS. 2017. A case of pentastomiasis at the left maxilla bone in a patient with thyroid cancer. Korean J Parasitol. 55:433-437.

Corrente M, Sangiorgio G, Grandolfo E, Bodnar L, Catella C, Trotta A, Martella V, Buonavoglia D. 2017. Risk for zoonotic Salmonella transmission from pet reptiles: A survey on knowledge, attitudes and practices of reptile-owners related to reptile husbandry. Prevent Vet Medic. 146:73-78.

Doornbos K, Sumrandee C, Ruang-Arrerate T, Baimai V, Trinachartvanit W, Ahantarig A. 2013. Rickettsia sp. closely related to Rickettsia raoultii (Rickettsiales: Rickettsiaceae) in an Amblyomma helvolum (Acarina: Ixodidae) tick from a Varanus salvator (Squamata: Varanidae) in Thailand. J Med Entomol. 50:217-220.

Eibach D, Krumkamp R, Al-Emran HM, Sarpong N, Hagen RM, Adu-Sarkodie Y, Tannich E, May J. 2015. Molecular characterization of Cryptosporidium spp. among children in rural Ghana. PLoS Negl Trop Dis. 9:1-12.

Emerson YSY. 2012. First record of Varanus bitatawa in the Philippine pet trade. Biawak. 6:73.

Galecki R, Sokól R, Dudek A. 2016. Tongue worm (Pentastomida) infection in ball pythons (Python regius) – a case report. Ann Parasitol. 62:363-365.

Hanafiah M, Alfiansyah HD, Sayuti A. 2018. Identifikasi parasit pada biawak air (Varanus salvator). Jurnal Sain Veteriner. 36:24-31.

Hashmi MUA, Khan MZ, Amtyaz, Ul Huda N. 2013. Current status, distribution and threats of varanus species (Varanus bengalensis & Varanus griseus) in Karachi & Thatta of Sindh. Int J Fauna Biologic Stud. 1:34-38.

Hooshyar H, Rostamkhani P, Arbabi M, Delavari M. 2019. Giardia lamblia infection: Review of current diagnostic strategies. Gastroenterol Hepatol Bed Bench. 12:3-12.

Hughes-Hanks JM, Schommer SK, Mitchell WJ, Shaw DP. 2010. Hepatitis and enteritis caused by a novel herpesvirus in two monitor lizards (Varanus spp.). J Vet Diagn Invest. 22:295–299.

Huminto H, Agungpriyono DR. 2008. Deadly adenoviral infection in a lizard (Varanus salvator). Proceeding of AZWMC. Bogor, 19-22 Agustus 2008. Bogor (Indonesia). p. 40-41.

Hyndman T, Shilton CM. 2011. Molecular detection of two adenoviruses associated with disease in Australian lizards. Australian Vet J. 89:232-235.

Hyndman TH, Howard JG, Doneley RJT. 2019. Adenovirus in free-ranging Australian bearded dragons (Pogona spp.). Vet Microbiol. 234:72-76.

Indraswari AAS, Suwiti NK, Apsari IAP. 2017. Protozoa gastrointestinal: Eimeria auburnensis dan Eimeria bovis menginfeksi sapi bali betina di Nusa Penida. Buletin Vet Udayana. 9:112-116.

Jaleta TG, Zhou S, Bemm FM, Schar F, Khieu V, Muth, S, Odermatt P, Lok JB, Streit A. 2017. Different but overlapping populations of Strongyloides stercoralis in dogs and humans—Dogs as a possible source for zoonotic strongyloidiasis. PLoS Negl Trop Dis. 11:e0005752. doi: 10.1371/journal.pntd.0005752.

Jho Y-S, Park D-H, Lee J-H, Cha S-Y, Han J-S. 2011. Identification of bacteria from the oral cavity and cloaca of snakes imported from Vietnam. Laboratory Anim Res. 27:213-217.

Johny J, Kumar A, Kolar VV, Hamide A. 2018. Eosinophilic meningitis caused by consumption of meat of monitor lizard (Varanus bengalensis). Neurol India. 66:1166.

Kadariya J, Smith TC, Thapaliya D. 2014. Staphylococcus aureus and Staphylococcal Food-Borne Disease: An ongoing challenge in public health. BioMed Res Int. 2014:1-9.

Kaenkan W, Nooma W, Chelong I, Baimai V, Trinachartvanit W, Ahantarig A. 2019. Reptile-associated Borrelia spp. in Amblyomma ticks, Thailand. Ticks Tick-borne Dis. 11:1-23.

Karunarathna DMSS, Amarasinghe AAT, Madawala MB, Kandambi HKD. 2012. Population status of two varanus species (Reptilia: Sauria: Varanidae) in Sri Lanka’s puttalam lagoon system, with notes on their diet and conservation Status. Biawak. 6:22-33.

Koch A, Ziegler T, Böhme W, Arida E, Auliya M. 2013. Pressing problems: Distribution, threats, and conservation status of the monitor lizards (Varanidae: Varanus spp.) of Southeast Asia and the Indo-Australian archipelago. Herpetologic Conserv Biol. 8:1-62.

Koh FX, Panchadcharam C, Sitam FT, Tay ST. 2018. Molecular investigation of Anaplasma spp. in domestic and wildlife animals in Peninsular Malaysia. Vet Parasitol: Regional Studies and Report. 13:141-147.

Kubiak M. 2013. Detection of agamid Adenovirus-1 in clinically healthy bearded dragons (Pogona vitticeps) in the UK. Vet Record. 172(18):475.

Lin M, Kikuchi T, Brewer HM, Norbeck AD, Rikihisa Y. 2011. Global proteomic analysis of two tick-borne emerging zoonotic agents: Anaplasma phagocytophilum and Ehrlichia chaffeensis. Frontiers in Microbiology. 2:1-19. doi:10.3389/fmicb.2011.00024.

Mackenzie JS, Jeggo M. 2019. The One Health Approach—Why is it so important?. Tropl Med and Infect Dis. 4(2):88. doi: 10.3390/tropicalmed4020088

Maldonado Júnior A, Simões RO, Oliveira APM, Motta EM, Fernandez MA, Pereira ZM, Monteiro SS, Torres EJS, Thiengo SC. 2010. First report of Angiostrongylus cantonensis (Nematoda: Metastrongylidae) in Achatina fulica (Mollusca: Gastropoda) from Southeast and South Brazil. Memórias Do Instituto Oswaldo Cruz. 105(7):938–941. doi:10.1590/s0074-02762010000700019.

Manjunatha V, Rout M, Muniyellappa HK, Roopa S, Shivashankar BP, Byregowda SM. 2020. Pathological conditions associated with Physaloptera stomach worm infestation in bengal monitor lizard (Varanus bengalensis). Indian J Anim Res. 54(4):473-477.

Marschang RE. 2011. Viruses infecting reptiles. Viruses. 3(11):2087–2126.

Maryanti E. 2011. Epidemiologi kriptosporidiosis. J Ilmu Kedokteran. 5(1):1-6.

Michaely LM, von Dornberg K, Molnar V, Tappe D, Tannich E, Hewicker-Trautwein M, Wohlsein P. 2020. Entamoeba ranarum infection in a ball python (Python regius). J. Comp. Path. 179:74-78.

Murphy D, Oshin F. 2014. Reptile-associated salmonellosis in children aged under 5 years in South West England. Arch Dis Child. 0:1-2.

Nabarro L, Morris-Jones S, Moore DAJ. 2020. Arthropod-borne diseases. In: Peter’s Atlas of Tropical Medicine and Parasitology. 7th ed. London (United Kingdom): Elsevier. p. 1–108.

Nejsum P, Betson M, Bendall RP, Thamsborg SM, Stothard JR. 2012. Ascaris suum and Trichuris suis: looking to the future from an analysis of the past. Journal of Helminthology. 86:148-155.

Nijman V. 2016. Perceptions of sundanese men towards the consumption of water monitor lizard meat in west java, indonesia. Biawak. 10(1):22-25.

Nikousefat Z, Javdani M, Hashemnia M, Rezaei F, Chalechale A. 2014. Hematology of a green iguana infected by Entamoeba invadense. Online J Vet Res. 18(11):851-858.

Nowak M, Cieniuch S, Stanczak J, Siuda K. 2010. Detection of Anaplasma phagocytophilum in Amblyomma flavomaculatum ticks (Acari: Ixodidae) collected from lizard Varanus exanthematicus imported to Poland. Exp Appl Acarol. 51:363–371.

Nurkarimah AB, Mufasirin, Damayanti R, Suwanti LT, Setiawan B, Suprihati E. 2020. Identification of protozoa in the blood and digestive tract on water monitor lizard (Varanus salvator). Journal of Parasite Science. 4(1):31-36.

Odeyemi OA. 2016. Public health implications of microbial food safety and foodborne disease in developing countries. Food & Nutrition Research. 60: 29819.

O’Donoghue P. 2017. Haemoprotozoa: Making biological sense of molecular phylogenies. International Journal for Parasitology: Parasites and Wildlife. 6:241-256.

Pavlasek I, Ryan U. 2008. Cryptosporidium varanii takes precedence over C. saurophilum. Experiment Parasitol. 118:434–437.

Pees M, Rabsch W, Plenz B, Fruth A, Prager R, Simon S, Schmidt V, Münch S, Braun PG. 2013. Evidence for the transmission of Salmonella from reptiles to children in Germany, July 2010 to October 2011. Euro Surveill. 18:1-11.

Pénzes JJ, Szirovicza L, Harrach B. 2020. The complete genome sequence of bearded dragon adenovirus 1 harbors three genes encoding proteins of the C-type lectin-like domain superfamily. Infect Genet Evol. 83:1-12.

Prado-Irwin SR, van de Schoot M, Geneva AJ. 2018. Detection and phylogenetic analysis of adenovirus occuring in a single species. Peer J. 6:1-18.

Putri BR, Suprihati E, Yunus M, Koesdarto S, Suwanti LT, Kusnoto. 2020. Morphology of surface ultrastructure of Duthiersia expansa (Cestoda: Diphyllobothriidea) from water lizards (Varanus salvator) from Sidoarjo, Indonesia. J Phys: Conf Ser. 1430 012014:1-6.

Raksanagara AS, Raksanagara A. 2015. Perilaku hidup bersih dan sehat sebagai determinan kesehatan yang penting pada tatanan rumah tangga di Kota Bandung. Jurnal Sistem Kesehatan. 1:30-34.

Reeves WK, Durden LA, Dasch GA. 2006. A spotted fever group rickettsia from an exotic tick species, Amblyomma exornatum (Acari: Ixodidae), in a reptile breeding facility in the United States. J Med. Entomol. 43:1099-1101.

Ryan U, Fayer R, Xiao L. 2014. Cryptosporidium species in human and animals: current understanding and research needs. Parasitology. 141:1667-1685.

Ryan U, Hijjawi N. 2015. New developments in Cryptosporidium research. Int J Parasitol. 45:367-373.

Scheelings TF, Jessop TS. 2011. Influence of capture method, habitat quality and individual traits on blood parameters of free-ranging lace monitors (Varanus varius). Australian Vet J. 89:360-365.

Shilton CM, Šlapeta J, Shine R, Brown GP. 2018. Invasive colonic entamoebiasis in wild cane toads, Australia. Emerg Infect Dis. 24:1541-1543.

Shin SP, Kim JH, Gomez DK, Choresca CH, Han JE, Park SC. 2009. Isolation and characterization of Morganella morganii from asian water monitor Varanus salvator. J Vet Clin. 26:391-394.

Sparks H, Nair G, Castellanos-Gonzalez A, White Jr. AC. 2015. Treatment of cryptosporidium: What we know, gaps, and the way forward. Curr Trop Med Rep. 2:181-187.

Subroto AY, Sardjana IKW, Sukmanadi M, Poetranto ED, Kusnoto, Sunarso A. 2020. Identification of pentastomide parasites in consumed water lizard (Varanus salvator). J Parasite Sci. 4:41-44.

Subramanean J, Reddy MV. 2012. Monitor lizards and geckos used in traditional medicine face extinction and need protection. Curr Sci. 102:1248-1249.

Supriyono, Takano A, Kuwata R, Shimoda H, Hadi UK, Setiyono A, Agungpriyono S, Maeda K. 2019. Detection and isolation of tick-borne bacteria (Anaplasma spp., Rickettsia spp., and Borrelia spp.) in Amblyomma varanese ticks on lizard (Varanus salvator). Microbiol Immunol. 63:328-333.

Tomastikova Z, Romero SB, Knotek Z, Karpiskova R. 2017. Prevalence and characteristics of Salmonella species from captive reptiles in the Czech Republic. Veterinarni Medicina. 62:456-469.

Uyeda L, Iskandar E, Purbatrapsila A, Pamungkas J, Wirsing A, Kyes R. 2014. Water monitor lizard (Varanus salvator) satay: A treatment for skin ailments in muarabinuangeun and cisiih, Indonesia. Biawak. 8:35-38.

Wellehan JFX, Johnson AJ, Latimer KS, Whiteside DP, Crawshaw GJ, Detrisac CJ, Terrell SP, Heard DJ, Childress A, Jacobson ER. 2005. Varanid herpesvirus 1: a novel associated with proliferative stomatitis in green tree monitors (Varanus prasinus). Vet Microbiol. 105:83-92.

Widisuputri NKA, Suwanti LT, Plumeriastuti H. 2020. A Survey for zoonotic and other gastrointestinal parasites in pig in Bali Province, Indonesia. Indones J Trop Infect Dis. 8:55-66. doi: 10.20473/ijtid.v8i1.10393.

Wozniakowski G, Samorek-Salamonowicz E. 2015. Animal herpesviruses and their zoonotic potential for cross-species infection. Ann Agric Environ Medic. 22:191–194.


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