Surra: Trypanosomiasis in Livestock is Potential as Zoonotic Disease

April Hari Wardhana, Dyah H Savitri


Trypanosoma evansi is one of blood protozoans having the most wide distribution region compared to other Trypanosome species. The parasite causes trypanosomiasis known as Surra. The disease may cause mortality to the infected animals. In general T evansi only attack animal and cannot infect humans due to apolipoprotein 1 (Apo L-1) in human serum. The protein possess trypanolitic activity feature against T. evansi and effectively eliminates the protozoa. However, the knowledge of Surra infecting animals changed because there were atypical human trypanosomiasis cases reported in some countries due to T. evansi. The human Surra case occurred in Vietnam demonstrated that person with Apo L-1 could be infected by T. evansi. There was resistant strain of T. evansi found which able to disrupt human immune system. This paper will discuss Surra cases in both humans and animals, including mechanism of Apo L-1 on eliminating the parasite. Surra cases in human and animal should be seriously concerned because Surra could be pontential zoonosis threating human health.


Trypanosoma evansi; zoonosis; Surra; apolipoprotein; trypanosomiasis

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Abdel-Rady A. 2008. Epidemiological studies (parasitological, serological and molecular techniques) of Trypanosoma evansi infection in camels (Camelus dromedarius) in Egypt. Vet World. 1:325-328.

Brun R. 2005. Human asian trypanosomiasis, a new threat to human health? Am J Trop Med Hyg. 73:484.

Chau NVV, Chau LB, Desquesnes M, Herder S, Lan NPH, Campbell JI, Cuong N Van, Yimming B, Chalermwong P, Jittapalapong S, et al. 2016. A clinical and epidemiological investigation of the first reported human infection with the zoonotic parasite Trypanosoma evansi in Southeast Asia. Clin Infect Dis. 62:1002-1008.

Desquesnes M, Bossard G, Thévenon S, Patrel D, Ravel S, Pavlovic D, Herder S, Patout O, Lepetitcolin E, Hollzmuller P, et al. 2009. Erratum to development and application of an antibody-ELISA to follow up a Trypanosoma evansi outbreak in a dromedary camel herd in France. Vet Parasitol. 162:214-220.

Desquesnes M, Dargantes A, Lai DH, Lun ZR, Holzmuller P, Jittapalapong S. 2013. Trypanosoma evansi and Surra: A review and perspectives on transmission, epidemiology and control, impact, and zoonotic aspects. Biomed Res Int. 2013:1-20.

Dia ML, Van Meirvenne N, Magnus E, Luckins AG, Diop C, Thiam A, Jacquiet P, Hamers R. 1997. Evaluation de quatre tests de diagnostic: Frottis sanguins, CATT, IFI et ELISA-Ag dans l’étude de l’épidémiologie de la trypanosomose cameline à Trypanosoma evansi en Mauritanie. Rev Elev Med Vet Pays Trop. 50:29-36.

Dobson RJ, Dargantes AP, Mercado RT, Reid SA. 2009. Models for Trypanosoma evansi (Surra), its control and economic impact on small-hold livestock owners in the Philippines. Int J Parasitol. 39:1115-1123.

Foil LD, Adams WV., McManus JM, Issel CJ. 1987. Blood meal residues on mouthparts of Tabanus fuscicostatus (diptera: Tabanidae) and the potential for mechanical transmission of pathogens. J Med Entomol. 24:613-616.

Gill B. 1977. Trypanosomes and Trypanosomiases of Indian livestock, Indian Council of Agricultural Research (ICAR).

Gutierrez C, Desquesnes M, Touratier L, Büscher P. 2010. Trypanosoma evansi: Recent outbreaks in Europe. Vet Parasitol. 174:26-29.

Haridy FM, El-Metwally MT, Khalil HH, Morsy TA. 2011. Trypanosoma evansi in dromedary camel: with a case report of zoonosis in greater Cairo, Egypt. J Egypt Soc Parasitol. 41:65-76.

Holland WG, Thanh NG, Do TT, Sangmaneedet S, Goddeeris B, Vercruysse J. 2005. Evaluation of diagnostic tests for Trypanosoma evansi in experimentally infected pigs and subsequent use in field surveys in North Vietnam and Thailand. Trop Anim Health Prod. 37:457-467.

Joshi PP, Chaudhari A, Shegokar VR, Powar RM, Dani VS, Somalwar AM, Jannin J, Truc P. 2006. Treatment and follow-up of the first case of human trypanosomiasis caused by Trypanosoma evansi in India. Trans R Soc Trop Med Hyg. 100:989-991.

Joshi PP, Shegokar VR, Powar RM, Herder S, Katti R, Salkar HR, Dani VS, Bhargava A, Jannin J, Truc P. 2005. Human trypanosomiasis caused by Trypanosoma evansi in India: The first case report. Am J Trop Med Hyg. 73:491-495.

Kocher A, Desquesnes M, Yangtara S, Morand S, Jittapalapong S. 2015. Is the oriental house rat (Rattus tanezumi) a potential reservoir for Trypanosoma evansi in Thailand? J Wildl Dis. 51:719-723.

Kumar R, Kumar S, Khurana SK, Yadav SC. 2013. Development of an antibody-ELISA for seroprevalence of Trypanosoma evansi in equids of North and North-Western regions of India. Vet Parasitol. 196:251-257.

Lai DH, Wang QP, Li Z, Luckins AG, Reid SA, Lun ZR. 2010. Investigations into human serum sensitivity expressed by stocks of Trypanosoma brucei evansi. Int J Parasitol. 40:705-710.

Liu B, Liu Y, Motyka SA, Agbo EEC, Englund PT. 2005. Fellowship of the rings: The replication of kinetoplast DNA. Trends Parasitol. 21:363-369.

Luckins AG. 1994. Equine trypanosomiasis. Exotic disease series. Equine Vet Educ. 6:259-262.

Lun ZR, Reid SA, Lai DH, Li FJ. 2009. Atypical human trypanosomiasis: A neglected disease or just an unlucky accident? Trends Parasitol. 25:107-108.

Milocco C, Kamyingkird K, Desquesnes M, Jittapalapong S, Herbreteau V, Chaval Y, Douangboupha B, Morand S. 2013. Molecular demonstration of Trypanosoma evansi and Trypanosoma lewisi DNA in wild rodents from Cambodia, Lao PDR and Thailand. Transbound Emerg Dis. 60:17-26.

Misra KK, Roy S, Choudhury A. 2016. Biology of Trypanosoma (Trypanozoon) evansi in experimental heterologous mammalian hosts. J Parasit Dis. 40:1047-1061.

Nguyen QD, Nguyen TT, Pham QP, Le NM, Nguyen GTT, Inoue N. 2013. Seroprevalence of Trypanosoma evansi infection in water buffaloes from the mountainous region of North Vietnam and effectiveness of trypanocidal drug treatment. J Vet Med Sci. 75:1267–-269.

Njiru ZK, Ouma JO, Enyaru JC, Dargantes AP. 2010. Loop-mediated isothermal amplification (LAMP) test for detection of Trypanosoma evansi strain B. Exp Parasitol. 125:196-201.

OIE. 2012. Trypanosoma evansi infection (Surra). Paris (France): OIE.

Otto MA, Silva ASD, Gressler LT, Farret MH, Tavares KCS, Zanette RA, Miletti LC, Monteiro SG. 2010. Susceptibility of Trypanosoma evansi to human blood and plasma in infected mice. Vet Parasitol. 168:1-4.

Parashar R, Singla LD, Kaur P. 2016. Is Atypical human trypanosomosis an emering threat to human society?: A debatable one health issue to public health experts and parasitologists. Int J Vet Sci Res. 2:36-41.

Pays E, Vanhollebeke B. 2008. Mutual self-defence: The trypanolytic factor story. Microbes Infect. 10:985-989.

Pays E, Vanhollebeke B, Vanhamme L, Paturiaux-Hanocq F, Nolan DP, Pérez-Morga D. 2006. The trypanolytic factor of human serum. Nat Rev Microbiol. 4:477-486.

Powar R, Shegokar V, Joshi P, Dani V, Tankhiwale N, Truc P, Jannin J, Bhargava A. 2006. A rare case of human trypanosomiasis caused by Trypanosoma Evansi. Indian J Med Microbiol. 24:72-74.

Pumhom P, Pognon D, Yangtara S, Thaprathorn N, Milocco C, Douangboupha B, Herder S, Chaval Y, Morand S, Jittapalapong S, Desquesnes M. 2014. Molecular prevalence of Trypanosoma spp in wild rodents of Southeast Asia: Influence of human settlement habitat. Epidemiol Infect. 142:1221-1230.

Queiroz AO, Cabello PH, Jansen AM. 2000. Biological and biochemical characterization of isolates of Trypanosoma evansi from pantanal of Matogrosso - Brazil. Vet Parasitol. 92:107-118.

Rademaker V, Herrera HM, Raffel TR, D’Andrea PS, Freitas TPT, Abreu UGP, Hudson PJ, Jansen AM. 2009. What is the role of small rodents in the transmission cycle of Trypanosoma cruzi and Trypanosoma evansi (kinetoplastida trypanosomatidae)? A study case in the Brazilian Pantanal. Acta Trop. 111:102-107.

Raina AK, Kumar R, Sridhar VSR, Singh RP. 1985. Oral transmission of Trypanosoma evansi infection in dogs and mice. Vet Parasitol. 18:67-69.

Ravindran R, Rao J, Mishra A, Pathak K, Babu N, Satheesh C, Rahul S. 2008. Trypanosoma evansi in camels, donkeys and dogs in India: Comparison of PCR and light micrscopy for detection-short communication. Veternarski Arh. 78:89-94.

Reid SA, Husein A, Copeman DB. 2001. Evaluation and improvement of parasitological tests for Trypanosoma evansi infection. Vet Parasitol. 102:291-297.

Rodríguez NF, Tejedor-Junco MT, Hernández-Trujillo Y, González M, Gutiérrez C. 2010. The role of wild rodents in the transmission of Trypanosoma evansi infection in an endemic area of the Canary Islands (Spain). Vet Parasitol. 174:323-327.

Salim B, de Meeûs T, Bakheit MA, Kamau J, Nakamura I, Sugimoto C. 2011. Population genetics of Trypanosoma evansi from camel in the Sudan. PLoS Negl Trop Dis. 8:e3417.

Sawitri DS. 2016. Studi virulensi Trypanosoma evansi isolat Indonesia dengan penentuan marka molekular DNA mikrosatelit dan analisis profil sitokin pada mencit (Mus musculus). Fakultas Kedokteran, Program Doktor Ilmu Biomedik. Universitas Indonesia. Jakarta.

Shegokar VR, Powar RM, Joshi PP, Bhargava A, Dani VS, Katti R, Zare VR, Khanande VD, Jannin J, Truc P. 2006. Short report: Human trypanosomiasis caused by Trypanosoma evansi in a village in India: Preliminary serologic survey of the local population. Am J Trop Med Hyg. 75:869-870.

Da Silva AS, Duck MRK, Fanfa VDR, Otto MA, Nunes JTS, Tonin AA, Jaques JA, Paim FC, Duarte MMMF, Monteiro SG. 2012. Trypanocidal activity of human plasma on Trypanosoma evansi in mice. Rev Bras Parasitol Veterinária. 21:55-59.

Da Silva AS, Wolkmer P, Tavares KCS, Gressler LT, Otto MA, Bess F, Zanette RA, Monteiro SG. 2009. Patogenicidade do um isolado de Trypanosoma evansi em ratos inoculados com o parasito em sangue in nature e criopreservado. Ciência Rural. 39:1842-1846.

Silva RAMS, Barros ATM, Herrera HM. 1995. Trypanosomosis outbreaks due to Trypanosoma evansi in the Pantanal, Brazi. A preliminary approach on risk factors. Rev D’Élevage Médicine Véterinaire dês Pays Trop. 48:315-319.

Da Silva SA, Neto OASDA, Costa MM, Wolkmer P, Mazzantti CM, Santurio JM, Lopes STDA, Monteiro G. 2010. Tripanossomose em equinos na região sul do Brasil. Acta Sci Vet. 38:113-120.

Sim ST, Wiwanitkit V. 2015. Emerging human trypanosomiasis in Southeast Asia: A coming new threat? J Nat Sci. 1:e29.

Singla LD, Sumbria D. 2016. Human atypical trypanosomosis in Indian Subcontinent. Veterinaria. 4:7-10.

Tejero F, Roschman G, Carmona A, Mercedes T, Aso P. 2008. Trypanosoma evansi: A quantitative approach to the understanding of the morphometry-hematology relationship throughout experimental murine infections. Protozool Res. 18:34-47.

Touratier L, Das S. 2006. Confirmation et suspicion de trypanosome humaine a Trypanosoma evansi dans des zones a forte prevalence de Surra. In: Prem recontre algero-francaise Parasitol. Algiers (Algeria).

Truc P, Gibson W, Herder S. 2007. Genetic characterization of Trypanosoma evansi isolated from a patient in India. Infect Genet Evol. 7:305-307.

Truc P, Büscher P , Cuny G, Gonzatti MI, Jannin J, Joshi P, Juyal P, Lun ZR, Mattioli R, Pays E, Simarro PP, Teixeira MM, Touratier L, Vincendeau P, Desquesnes M. 2013. Atypical human infections by animal trypanosomes. Plos Negl Trop Dis. 7.e2256: 1 -7.

Tuntasuvan D, Luckins A. 1998. Status Surra in livestock in Thailand. J Protozool Res. 8:162-170.

Vanhollebeke B, Truc P, Poelvoorde P, Pays A, Joshi PP, Katti R, Jannin JG, Pays E. 2006. Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I. N Engl J Med. 355:2752-2756.

Vergne T, Kamyinkird K, Desquesnes M, Jittapalapong S. 2011. Attempted transmission of Trypanosoma evansi to rats and mice by direct ingestion of contaminated blood and via engorged ticks. Acta Protozool. 50:133-136.

Wabale V, Nalage P, Joshi A, Bharadwaj R, Desphande K, Chowdary A. 2015. Human asian trypanosomiasis due to Trypanosoma evansi: A rare case. J Adv Parasitol. 2:65-68.

Warpe BM, More S V. 2014. A rare Indian case of human trypanosomiasis caused by Trypanosoma lewisi-like parasites. J Biosci Technol. 5:564-567.

Womack S, Tarpley HL, Little SE, Latimer KS. 2006. Trypanosoma evansi in Horses. Vet Clin Path Clerksh Program. 2006:1-5.

Xie J, Shen YL, Wang ZK. 1998. Selection of human serum resistant clone of Trypanosoma brucei evansi. J Nanjing Agric Univ. 21:98-101.

Van Xong H, De Baetselier P, Pays E, Magez S. 2002. Selective pressure can influence the resistance of Trypanosoma congolense to normal human serum. Exp Parasitol.


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