The Potential of Bioactive Compound Moringa Leaf to Improve Rabbit Reproductive Performance

Setiasih Setiasih, Ahmad Mualif Abdurrahman, Hendrawan Soetanto

Abstract

Moringa leaf is a potential animal feed material because it has a complete nutrient content as well as many bioactive compounds. Among its bioactive compounds are phytosterols and isoflavones. This paper aims to describe the importance of moringa leaf as feed supplementation to improve rabbit reproductive performance. The bioactive compounds in moringa leaf  have an important role  to trigger  reproductive hormones.. Phytosterols have a chemical structure similar to that of cholesterol that can be used as precursors of steroid hormones (testosterone, estradiol and progesterone). Isoflavones are one  of the flavonoid compounds, also have  estrogenic activity and are able to bind with estrogen receptors i.e. ER-α and ER-β. Because of these bioactive compounds, moringa leaves are potential to  be utilized as feed supplements as aphrodisiac for bucks, stimulating estrous, and increasing litter size and milk production of does, reduce mortality and increase weaning weight and average daily gain of bunnies.

Keywords

Moringa oleifera; phytosterols; isoflavones; reproduction; rabbit

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References

Abu AH, Ahemen T, Ikpechukmu P. 2013. The testicular morphometry and sperm quality of rabbit bucks fed graded levels of Moringa oleifera leaf meal (Molm). Agrosearch. 13:49-56.

Antonette ME, Hernandez A, Benjamin G. 2002. A comparative study on the efficacy of the different galactagogues among mothers with lactational insufficiency. Philippine J Pediatrics. 51:88-92.

Alemede IC, Onyeji EA, Tsado DN, ShiawoyaEL. 2014. Reproductive response of rabbits dose to diets containing varying levels of horseradish (Moringa oleifera) leaf meal. J Biol Agric Healthcare. 4:62-68.

Anwar F, Latif S, Asraf M, Gilani AH. 2007. Moringa oleifera: A food plant with multiple medicine uses. Phytother Res. 21:17-25.

Ayodele AE, Adeola JR, Mayowa AT. 2014. Reproductive performance of rabbit does fed graded levels of Moringa oleifera leaf meal based diet. Int J Sci. 3:49-53.

Bennett RN, Mellon FA, Foidl N, Pratt DU, Pont MS, Perkins L, Kroon PA. 2003. Profiling glucosinolates and phenolic in vegetative and reproductive tissue of the multipurpose tree. Moringa oleifera L (horseradish tree) and Moringa stenopetala L. J Agric Food Chem. 51:3546-3553.

[Dirjen PKH] Direktorat Jenderal Peternakan dan Kesehatan Hewan. 2020. Populasi kelinci menurut propinsi 2015–2019. [Diakses pada 28 Desember 2020]. Available from: https://www.pertanian.go.id/home/ index.php?show=repo&fileNum=419.

Estrella MCP, Jacinto Blas V MD, MantaringMD, David GZ, Michelle A, TaupM.D. 2000. A double-blind, randomized controlled trial on the use of malunggay (Moringa oleifera) for augmentation of the volume of breastmilk among non-nursing mothers of paterm infants. Philippine J Pediatry. 49:3-6.

Fahey JW. 2005. Moringa oleifera: A review of the medical evidence for its nutritional, therapeutic, and prophylactic properties part 1. Trees Life J. 1(5).

Iqbal MF, Khan RNA, Hashim MM, Ahmad T, Mian AA, Ishaq K, Rehman A. 2013. Formononetin influences growth and immune responses in broilers. Pak J Zool. 45:1015–1020.

Iwuji, TC, Obiejezie, NR, Ogbuewu IP, Etuk IF, Ahiwe EU, Kadurumba OE, Ezea J. 2016. Reproductive and haemato-biochemical influence of aqueous extracts of Moringa oleifera leaves on adult New Zealand Rabbit Bucks. Int J Life Sci Technol. 9:74-80.

Jalaludeen AM, Ha WT, Lee R, Kim JH, Do JT, Park C, Heo YT, Lee WY, Song H. 2016. Biochanin a ameliorates arsenic-induced hepato- and hematotoxicity in rats. Molecules. 21:1–15.

Ji ZN, Zhao WY, Liao GR, Choi RC, Lo CK, Dong TTX, Tsim KWK. 2006. In vitro estrogenic activity of formononetin by two bioassay systems. Gynecol Endocrinol. 22:578–584.

Karthivashan G, Arulselvan P, Alimon AR, Ismail IS, FakuraziS. 2015. Competing role of bioactive constituents in Moringa oleifera extract and conventional nutrition feed on the performance of Cobb 500 broilers. BioMed Res Int. 4:112-120.

Kleden MM, Soetanto H, Kusmartono, Kuswanto. 2017. Concentration of progesterone and prolactin hormones and milk production of New Zealand White rabbits doe fed moringa leaves meal. Mediterranean J Soc. 8:79-86.

Lebas F, Coudert P, Rouvier R, de Rochambeau H. 1986. The rabbit. husbandry, health and production. Rome (Italy): Food and Agricultural Organization of United Nations. p. 21-65.

Leone A, Spada A, Battezzati A, Schiraldi A, Aristil J, Bertoli S. 2015. Cultivation, genetic, ethnopharmacology, phytochemistry and pharmacology of Moringa oleifera leaves: An overview. Int J Molec Sci. 16:791–835.

Lilibeth AC, Glorina LP. 2010. Effects Moringa oleifera lam (Moringaceac) on the reproduction of male mice (Mus musculus). J Med Plant Res. 4:115-121.

Lollivier VP, Marnet G, Delpal S, Rainteau D, Archard C, Rabot A, Bousquet MO. 2006. Oxytocin stimulates secretory processes in lactating rabit mammary ephithelial cells. J Physiol. 570:125-140.

Luthfi M, Firdaus F, Affandhy L. 2019. Peningkatan libido dan hormon testosteron melalui suplementasi herbal pada sapi pejantan PO. Prosiding Seminar Nasional Teknologi Peternakan dan Veteriner. Bogor (Indonesia): IAARD Press. hlm. 83-88.

Malik A, Gunawan A, Erlina S, Widaningsih N, Elvania R, Zuraidah A, Kholik A, Suyanto, Mawardi. 2020. Effect addition of urea molasses multi-nutrient moringa block (UM3B) on the ovarian follicular dynamics in crossbred cows. Short Communication. Adv Anim Vet Sci. 8:458-462.

Mohammed AA, Iyeghe-Erakpotobor GT, Zahraddeen D, Barje PP, Samuel FU. 2019. Growth and reproductive performance of rabbit does fed Moringa oleifera leaf meal based diets supplemented with garlic, ginger or black pepper. J Anim Prod Res. 31:74-87.

Muelas R, Cano P, Garcia ML, Esquifino A, Argente MJ. 2007. Influence of FSH, LH, and prolactin on the components of litter size in rabbit does. Xicato G, Trocino A, Lukefahr SD, editors. Proceedings of the 9th World Rabbit Congress, Verona, Italy, 10-13 June 2008. Castanet-Tolosan (France): World Rabbit Science Association. p. 405-410.

Mutiara KT. 2011. Uji efek pelancar ASI tepung daun kelor (Moringa oleifera (Lamk)) pada tikus putih galur Wistar [Disertasi]. [Malang (Indonesia)]: Universitas Brawijaya.

Mutiara KT, Harijono, Estiasih T, Wahyuni ES. 2013. Effect lactagogue Moringa leaves (Moringa oleifera Lam) powder in rats white female Wistar. J Basic Appl Sci Res. 3:430-434.

Nath D, Sethi N, Singh RK, Jain AK. 1992. Commonly used Indian abortifacient plants with special reference to their teratologic effect in rats. J Ethnopharmacol. 36:147-154.

Nuhu F. 2010. Effect of Moringa oleifera meal (MOLM) on nutrient digestibility, growth, carcas and blood indices of weaner rabbit [Thesis]. [Kumasi (Ghana)]: Kwemw Nkrumah University of Science and Technology

Odeyinka SM, Oyedele OJ, Adeleke TO, Odedire JA. 2008. Reproductive performance of rabbits fed Moringa oleifera as a replacement for Centrosema pubescens. Xicato G, Trocino A, Lukefahr SD, editors. Proceedings of the 9th World Rabbit Congress, Verona, Italy, 10-13 June 2008. Castanet-Tolosan (France): World Rabbit Science Association. p. 411-415.

Odeyinka SM, 2013. Reproductive performance of rabbits fed Moringa oleifera and Moringa stenopetalaleave. Proceedings of Water, Food, Energy and Innovation for a Suitable World, ASA, CSSA and SSSA International Annual Mettings. Tampa, November 3-6, 2013. Florida (USA).

Olla SI, Williams OS, Obamojure IA, Okunlola AM, 2012. Sexual receptivity and conception rate of rabbit does fed selected perennial forages In Ile-Ife, Nigeria. Proceedings 10th World Rabbit Congress. Sharm El Seikh, September 3-6, 2012. Sharm El Sheikh (Egypt). p. 291-295.

Pawiroharsono S. 2001. Prospek dan manfaat isoflavon untuk kesehatan [Internet]. [disitasi 12 Pebruari 2016]. Tersedia dari: https://www.scribd.com/doc/ 117479146/Prospek-Dan-Manfaat-Isoflavon-Untuk-Kesehatan.

Potocka WB, Mannelli C, Boruszewska D, Lowalczyk-ZiebaI, Wasniewski T, Skarzynski DJ. 2013. Diverse effects of phytoestrogens on the reproductive performance: Cow as a model. Int J Endocrinol. 2013:1-15.

Raj A, Singh A, Sharma A, Singh N, Kumar P, Bhatia V. 2011. Antifertility activity of medicinal plants on reproductive system of female rat. Int J Bio-Engineering Sci Technol. 2:44-50.

Rajagopal PL, Premaletha K, Sreejith KR. A comprehensive review on safe galactogogues. World J Pharmaceutical Res. 5:1629-1640.

Ryokkynen A. 2006. Effects of phytoestrogens on reproduction and weight regulation of mammals [Dissertations]. [Joensuu (Finland)]: University of Eastern Finland.

Santell RC, Chang YC, Nair MG, Helferich WG. 1997. Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in rats. J Nutr. 127:263–269.

Setiasih. 2018. Pengaruh pemberian ekstrak daun kelor (Moringa oleifera, LAM) pada pakan terhadap perkembangan organ reproduksi, mekanismehormon dan kinerja reproduksi induk kelinci [Disertasi]. [Malang (Indonesia)]: Universitas Brawijaya.

Setiasih, Wahjuningsih S, Winarsih S, Soetanto H. 2019. The effects of adding Moringa oleifera leaves exctract on rabbit does’ milk production and mammary gland histology. Russ J Agric Socio-Econom Sci. 92:296-304.

Sánchez NR. 2006. Moringa oleifera and Cratylia argentea: Potential fodder species for ruminants in Nicaragua [Dissertation]. [Uppsala (Sweden)]: University of Agricultural Sciences Uppsala.

Suyanto, Malik Abd, Widaningsih N. 2020. Pemberian pakan tambahan urea molases multinutrien moringa blok (UM3B) terhadap timbul dan lama birahi sapi potong [internet]. [cited 5 Juni 2020]. Available from: http://eprints.uniskabjm.ac.id/438/1/JURNAL%20%28SUYANTO%29%20pdf.pdf.

Smith OB, Akinbamijo OO. 2000. Micronutrients and reproduction in farm animals. Anim Reprod Sci. 60–61:549–560.

Suprayogi A, Kusharto CM, Astuti DA. 2012. Produksi fraksi ekstrak daun katuk (Sauropus androgynous) sebagai bahan feed addictive dalam peningkatan kualitas kesehatan daging domba. Laporan Akhir Penelitian DIKTI. hlm. 10-15.

Tabares FP, Jaramillo JVB, Tatiana Ruiz-Cortés Z. 2014. Pharmacological overview of galactogogues. Vet Medic Int. 2014:1-20.

Tarsono, Najamudin, Mustaring, Duma Y, Supriono, 2009. Performa litter kelinci induk lokal yang diberi pakan hijauan ubi jalar disuplementasi sejumlah konsentrat berbeda. J Agroland. 16:78-84.

Tucket HA. 2000. Hormones, mammary growth and lactation. J Dairy Sci. 83:874-884.

Turner CD, Bagnara JT. 1998. Endokrinologi umum. edisi ke-6. Surabaya (Indonesia): Airlangga University Press. hlm. 564-642.

Toleng AL, Yusuf M, Sabile S. 2017. Peningkatan libido dan kualitas spermatozoa sapi bali melalui suplementasi akan blok tepung daun kelor. Prosiding Seminar Teknologi dan Agribisnis Peternakan V: Teknologi dan Agribisnis Peternakan untuk Mendukung Ketahanan Pangan, 18 November 2017. Purwokerto (Indonesia). hlm. 386-390.

Wadhwa S, Panwar MS, Saini N, Rawat S, Singhal S. 2013. A review on commercial, traditional uses, phytoconstituents and pharmacological activity of Moringa oleifera. Global J Trad Med Sys. 2:1-13.

Wu WH, Liu LY, Chung CJ, Jou HJ, Wang J. 2005. Estrogenic effect of yam ingestion in healthy post menoposal women. J Am Col Nutr. 24:235-243.

Xinmei X, Ning X, Jianbin H. 2015. Physiological function of phytosterol and its application. Anim Husbandry Feed Sci. 7:67–69.

Zhang JF, Peng DB, Lu R, Gao H, Zhou Z. 2010. Structure, electronic properties, and radical scavenging mechanisms of daidzein, genistein, formononetin, and biochanin A: A density functional study. J Molec Structure: Theochem. 955:1–6.

Zuppa A, Sindico A, Orchi P, Carducci C, Cardiello V, Romagnoli C, Catenazzi P.2010. Safety and efficacy of galactogogues: Substances that induce. Maintain and increase breast milk production. J Pharm Pharmaceut Sci. 13:162-174.

Zyood TAI, Shawakfa K. 2006. Phytosterol. Jordan (Jordan): University of Science of Technology. p. 25-32.

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