African Swine Fever: Penyakit Emerging yang Mengancam Peternakan Babi di Dunia

Indrawati Sendow, Atik Ratnawati, NLP I Dharmayanti, Muharam Saepulloh

Abstract

African swine fever (ASF) is a highly infectious disease in pigs that caused by the double-stranded DNA virus of the Asfarviridae family. The disease is characterized by haemorrhages in the ears, back and legs. This virus causes death in pigs and has a large economic impact. However, ASF is not a zoonotic disease, hence it has no an impact on human health. This paper  will discuss about ASF disease, route of transmision, how to diagnose, and handling of ASF. This disease has spread throughout Asia in a relatively short time in 2019, and this exotic disease has been reported entering Indonesia at the end of 2019. There is no effective prevention and control of the disease. Several vaccines have been developed but are still considered ineffective while commercial vaccines are not yet available. Safety and effectiveness of vaccines are still being considered because ASF virus is very unique and different from other DNA viruses,. Therefore, prevention of ASF infection should be done by conducting strict biosecurity, applying regulations on the movement of pigs and pig products to the region or country.

Keywords

African Swine Fever; characteristic; transmission; control; swill feeding

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References

Abworo EO, Onzere C, Amimo JO, Riitho V, Mwangi W, Davies J, Blome S, Bishop RP. 2017. Detection of African swine fever virus in the tissues of asymptomatic pigs in smallholder farming systems along the Kenya–Uganda border: Implications for transmission in endemic areas and ASF surveillance in East Africa. J General Virol. 98:1806-1814.

Alkhamis MA, Gallardo C, Jurado C, Soler A, Arias M, SaÂnchez-VizcaõÂno JM. 2018. Phylodynamics and evolutionary epidemiology of African swine fever p72-CVR genes in Eurasia and Africa. PLoS ONE. 13:e0192565.

Balyshev VM, Vlasov ME, Imatdinov AR, Titov I, Morgunov S, Malogolovkin AS. 2018. Biological properties and molecular-genetic characteristics of African Swine Fever virus isolated in various regions of Russia in 2016–2017. Russ Agric Sci. 44:469-473.

Beltran-Alcrudo DB, Falco JR, Raizman E, Dietze K. 2019. Transboundary spread of pig diseases: the role of international trade and travel. BMC Vet Res. 15:1-14.

Beltrán-Alcrudo D, Arias M, Gallardo C, Kramer S, Penrith ML. 2017. African swine fever: detection and diagnosis – A manual for veterinarians. FAO Animal Production and Health Manual No. 19. Rome (Italy): Food and Agriculture Organization of the United Nations.

Boinas FS, Wilson AJ, Hutchings GH, Martins C, Dixon LJ 2011. The persistence of African Swine Fever Virus in field-infected Ornithodoros erraticus during the ASF endemic period in Portugal. PLoS ONE. 6:e20383.

Cabezón O, Muñoz-González S, Colom-Cadena A, Pérez- Simó M, Rosell R, Lavín S, Marco I, Fraile L, de la Riva PM, Rodríguez F, Domínguez J, Ganges L. 2017. African swine fever virus infection in Classical swine fever subclinically infected wild boars. BMC Vet Res. 13:227.

Chenais E, Sternberg-Lewerin S, Boqvist S, Liu L, LeBlanc N, Aliro T, Masembe C, Ståhl K. 2017. African swine fever outbreak on a medium-sized farm in Uganda: Biosecurity breaches and within-farm virus contamination. Trop Anim Health Prod. 49:337-346.

Chenais E, Depner K, Guberti V, Dietze K, Viltrop A, Ståhl

K. 2019. Epidemiological considerations on African swine fever in Europe 2014–2018. Porc Heal Manag. 5:1-10.

Dione M, Ouma EA, Roesel K, Kungu J, Lule P, Pezo D. 2014. Participatory assessment of animal health and husbandrypractices in smallholder pig production systems in three highpoverty districts in Uganda. Preventive Vet Med. 117:565-576.

Dixon LK, Chapman DAG, Netherton CL, Upton C. 2013. African swine fever virus replication and genomics. Virus Res. 173:3-14.

[FAO] Food and Agriculture Organization of the United Nations. 2018. African Swine Fever threatens people ’s Republic of China: A rapid risk assessment of ASF introduction [Internet]: [accessed 2nd December 2019]. Available from: http://www.fao.org/3/ I8805EN/i8805en.pdf

Gaudreault NN, Richt JA. 2019. Sub-unit vaccine approaches for African Swine Fever virus. Vaccines. 7:1-20.

King K, Chapman D, Argilaguet JM, Fishbourne E, Hutet E, Cariolet R, Hutchings G, Oura CA, Netherton CL, Moffat K, Taylor G, Le Potier, MF, Dixon LK, Takamatsu HH. 2011. Protection of European domestic pigs from virulent African isolates of African swine fever virus by experimental immunisation. Vaccine. 29:4593-4600.

Kipanyula MJ, Nong’ona SW. 2017. Variations in clinical presentation and anatomical distribution of gross lesions of African swine fever in domestic pigs in the southern highlands of Tanzania: a field experience. Trop Anim Health Prod. 49:303-310.

Kolbasov DV, Balyshev VM, Sereda AD. 2014. Overall results of the development of African swine fever live vaccines. Veterinariya. 8:3-8.

Malogolovkin A, Burmakina G, Titov I, Sereda A, Gogin A, Baryshnikova E, Kolbasov D. 2015. Comparative analysis of African swine fever virus genotypes and serogroups. Emerg Infect Dis. 21:312-315.

Mazur-Panasiuk N, Woźniakowski G. 2019a. The unique genetic variation within the O174L gene of Polish strains of African swine fever virus facilitates tracking virus origin. Arch Vir. 164:1667-1672.

Mazur-Panasiuk N, Żmudzki J, Woźniakowski G. 2019b. African swine fever virus – persistence in different environmental conditions and the possibility of its indirect transmission. J Vet Res. 63:303-310.

Montgomery E. 1921. On a form of swine fever occurring in British East Africa (Kenya colony), J Comparative Path Therapeu. 24:159-191.

Mulumba-Mfumu LK, Goatley LC, Saegerman C, Takamatsu HH, Dixon LK. 2016. Immunization of African indigenous pigs with attenuated genotype I African swine fever virus OURT88/3 induces protection against challenge with virulent strains of genotype I. Transbound Emerg Dis. 63:e323–7.

Mur L, Atzeni M, Martinez-Lopez B, Feliziani F, Rolesu S, Sanchez-Vizcaino JM. 2016. Thirty-five-year presence of African Swine Fever in Sardinia: History, evolution and risk factors for disease maintenance. Transbound Emerg Dis. 63:e16577.

Mur L, Martinez-Lopez B, Sanchez-Vizcaino JM. 2012. Risk of African swine fever introduction into the European Union through transport-associated routes: returning trucks and waste from international ships and planes. BMC Vet. Res. 8:1-12.

Murgia MV, Mogler M, Certoma A, Green D, Monaghan P, Williams DT, Raymond R, Rowland R, Gaudreault NN. 2019. Evaluation of an African swine fever (ASF) vaccine strategy incorporating priming with an alphavirusexpressed antigen followed by boosting with attenuated ASF virus. Arch Vir. 164:359-370.

Nantima N, Ocaido M, Ouma E, Davies J, Dione M, Okoth E, Mugisha A, Bishop R. 2015. Risk factors associated with occurrence of African swine fever outbreaks in smallholder pig farms in four districts along the Uganda-Kenya border, Trop Anim Health Prod. 47:589-595.

Nefedeva MV, Titov IA, Mima KA, Malogolovkin AS. 2019. Analysis of the African Swine Fever virus immunomodulatory proteins. Mol Gen Microbiol Vir. 3:42-49.

Nix RJ, Gallardo C, Hutchings G, Blanco E, Dixon LK. 2006. Molecular epidemiology of African swine fever virus studied by analysis of four variable genome regions. Arch Virol. 151:2475-2494.

O’Donnell V, Holinka LG, Sanford B, Krug PW, Carlson J, Pacheco JM, Reese B, Risatti GR, Gladue DP, Borca MV. 2016. African swine fever virus Georgia isolate harboring deletions of 9GL and MGF360/505 genes is highly attenuated in swine but does not confer protection against parental virus challenge. Virus Res. 221:8-14.

[OIE] Organizacion Internacional de Epizootias. 2017. WAHID database, Disease information [Internet]: [accessed 2nd December 2019]. Available from: http://web.oie.int/wahis/public.php?page=disease_im mediate_summary.

Olesen AS, Lohse L, Boklund A, Halasa T, Gallardo C, Pejsak Z, Belsham GJ, Rasmussen TB, Botner A. 2017. Transmission of African swine fever virus from infected pigs by direct contact and aerosol routes. Vet Microbiol. 211:92-102.

Penrith ML, Vosloo W, Jori F, Basto AD. 2013. African swine fever virus eradication in Africa. Virus Res. 173:228-246.

Reis AL, Abrams CC, Goatley LC, Netherton C, Chapman DG, Sanchez-Cordon P. Dixon LK. 2016. Deletion of African swine fever virus interferon inhibitors from the genome of a virulent isolate reduces virulence in domestic pigs and induces a protective response. Vaccine. 34:4698-4705.

Rock DL. 2017. Challenges for African swine fever vaccine development–“perhaps the end of the beginning”. Vet Microbiol. 206: 52–58.

Rodriguez JM, Moreno LT, Alejo A, Lacasta A, Rodriguez F, Salas ML. 2015. Genome sequence of African swine fever virus BA71, the virulent parental strain of the nonpathogenic and tissue-culture adapted BA71V. PLoS One. 10:p.e0142889.

Sanchez-Vizcano JM, Mur L, Gomez-Villamandos JC, Carrasco JL. 2015. An update on the epidemiology and pathology of African swine fever. J Comp Pathol. 15:9-21.

Siamupa C, Saasa N, Phiri AM. 2017. Contribution of market value chain to the control of African swine fever in Zambia. Trop Anim Health Prod. 50:177-185.

Titov I, Burmakina G, Morgunov Y, Morgunov S, Koltsov A, Malogolovkin A, Kolbasov D. 2017. Virulent strain of African swine fever virus eclipses its attenuated derivative after challenge. Arch Virol. 162:3081- 3088.

Zhao D, Liu R, Zhang X, Li F, Wang J, Zhang J, Liu X, Wang L, Zhang J, Wu X, Guan Y, Chen W, Wang X, He X, Bu Z.2019. Replication and virulence in pigs of the first African swine fever virus isolated in China. Emerging Microbes Infect. 8:438-447.

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