Mycotoxin Contamination in the Food Chain

Eny Martindah, Sjamsul Bahri

Abstract

Mycotoxins contamination in animal feed is harmful to livestock and leads to residues, such as aflatoxin and its metabolites (aflatoxin M1, aflatoxicol, aflatoxin Q1 and aflatoxin P1) which are deposited in meat, milk, and eggs. The existence of mycotoxins has been widespread; and mycotoxin is the most important contaminant in the food chain because it has implications for human health. Mold growth and mycotoxin production mainly depend on the weather, such as warm temperatures (28-31°C) and high humidity (60-90%). Some types of mold can produce more than one type of mycotoxin and some mycotoxins can be produced by more than one species of fungi. Mycotoxins, especially aflatoxin, fumonisin, zearalenone, ochratoxin, deoxynivalenol, and T2 toxin present in feed and feedstuffs that have to be controlled. Mycotoxins are not only harmful to the health of consumers, but will also reduce the quality of the product that is contaminated, and cause economic losses. The risk of mycotoxin contamination in animal feed could be reduced by inhibiting the mould growth and toxin production, through crop rotation, using proper fungicides, and applying regulation of mycotoxins maximum limit in feed and food in order to prevent any danger to public health.

Keywords

Mycotoxin, food chain, health, animal, human

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References

Abdel-Wahhab MA, Kholif AM. 2008. Mycotoxins in animal feeds and prevention strategies: A review. Asian J Anim Sci. 2:7-25.

Agus A, Sumantri I, Murti TW, Boem J. 2013. Survey on the occurrence of aflatoxin B1 contamination in dairy ration and its carry over into the milk in Yogyakarta and Central Java Province of Indonesia. In: ISM-Mycored International Conference Europe 2013. Apulia, 27-31 May 2013. Apulia (Italy): CNR ISPA.

Alhousein A, Gurbuz Y. 2015. Aflatoxins in poultry nutrition. KSU J Nat Sci. 18:1-5.

Anastasia Y, Widiastuti R. 2015. Deteksi aflatoksin B1 pada pakan ayam menggunakan kromatografi cair spektrofotometri massa (KCSM). Dalam: Noor SM, Handiwirawan E, Martindah E, Widiastuti R, Sianturi RSG, Herawati T, Purba M, Anggraeny YN, Batubara A, penyunting. Teknologi Peternakan dan Veteriner untuk Peningkatan Daya Saing dan Mewujudkan Kedaulatan Pangan Hewani. Prosiding Seminar Nasional Teknologi Peternakan dan Veteriner. Jakarta, 8-9 Oktober 2015. Jakarta (Indonesia): Puslitbangnak. hlm. 496-504.

Arroyo-Manzanares N, Huertas-Pérez JF, García-Campaña AM, Gámiz-Gracia L. 2015. Aflatoxins in animal feeds: A straightforward and cost-effective analytical method. Food Control. 54:74-78.

Bahri S. 2015. Toksikologi veteriner: Tanaman beracun, mikotoksin, pestisida dan logam berat. Buku II. Bogor (Indonesia): IPB Press.

Bennett JW, Klich M, Mycotoxins M. 2003. Mycotoxins. Clin Microbiol Rev. 16:497-516.

Bhat R, Rai RV, Karim AA. 2010. Mycotoxins in food and feed: Present status and future concerns. Compr Rev Food Sci Food Saf. 9:57-81.

Binder EM. 2007. Managing the risk of mycotoxins in modern feed production. Anim Feed Sci Technol. 133:149-166.

Binder EM, Tan LM, Chin LJ, Handl J, Richard J. 2007. Worldwide occurrence of mycotoxins in commodities, feeds and feed ingredients. Anim Feed Sci Technol. 137:265-282.

Bryden WL. 1998. Mycotoxin contamination of Australian pasteurs and feedstuffs. In: Garland T, Barrr AC, editors. Toxic plants and other natural toxicants. New York (US): CABI Publishing. p. 464-468.

Bryden WL. 2007. Mycotoxins in the food chain: Human health implications. Asia Pac J Clin Nutr. 16:95-101.

Bryden WL. 2009. Mycotoxins and mycotoxicoses: significance, occurrence and mitigation in the food chain. In: Ballantyne B, Marrs T, Syversen T, editors. General and Applied Toxicology. 3rd Ed. Chichester (UK): John Wiley & Sons. p. 3529-3553.

Bryden WL. 2012. Mycotoxin contamination of the feed supply chain: Implications for animal productivity and feed security. Anim Feed Sci Technol. 173:134–158.

Creppy EE. 1999. Human ochratoxicosis. J Toxicol Toxin Rev. 18:277-293.

Dawlatana M, Coker RD, Nagler MJ, Wild CP, Hassan MS, Blunden G. 2002. The occurrence of mycotoxins in key commodities in Bangladesh: Surveillance results from 1993 to 1995. J Nat Toxins. 11:379-386.

Desjardins AE, Plattner RD. 2000. Fumonisin B (1)-nonproducing strains of Fusarium verticillioides cause maize (Zea mays) ear infection and ear rot. J Agric Food Chem. 48:5773-5780.

Dhanasekaran D, Shanmugapriya S, Thajuddin N, Panneerselvam A. 2011. Aflatoxins and aflatoxicosis in human and animals. In: Guevara-Gonzalez RG, editor. Aflatoxins-biochemistry and molecular biology. Rijeka (Croatia): InTech. p. 221-254.

Diaz GJ, Murcia HW. 2011. Biotransformation of aflatoxin B1 and its relationship with the differential toxicological response to aflatoxin in commercial poultry species. In: Guevara-Gonzalez RG, editor. Aflatoxins-biochemistry and molecular biology. Rijeka (Croatia): InTech. p. 3-20.

Duarte SC, Lino CM, Pena A. 2011. Ochratoxin A in feed of food-producing animals: An undesirable mycotoxin with health and performance effects. Vet Microbiol. 154:1-13.

Duarte SC, Lino CM, Pena A. 2012. Food safety implications of ochratoxin A in animal-derived food products. Vet J. 192:286-292.

Dutton MF. 1996. Fumonisins, mycotoxins of increasing importance: Their nature and their effects. Pharmacol Ther. 70:137-161.

El-Desouky TA, Mohamed SR, Abou-Arab AAK, Salim AB. 2014. Occurrence of aflatoxin B1 and M1 in some Egyptian chicken organs and their affected by ozonated water. Open Sci J Mod Phys. 1:24-30.

El-Nezami HN, Polychronaki, Salminen S, Mykkanen H. 2002. Binding rather than metabolism may explain the interaction of two foodgrade Lactobacillus strains with zearalenone and its derivative-zearalenol. Appl Environ Microbiol. 68:3545-3549.

European Commission. 2002. Directive 2002/32/EC of the European Parliament and of the council of 7 May 2002 on undesirable substances in animal feed. Off J Eur Communities. L 140:10-21.

European Commission. 2006. Commission Recommendation of 17 August 2006 on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding (2006/576/EU). Off J Eur Union. L 229:7-9.

European Communities. 2010. Commission Regulation (EU) No. 165/2010 of 26 February 2010 amending Regulation (EC) No 1881/2006 setting maximum levels for certain contaminants in foodstuffs as regards aflatoxins. Off J Eur Union. L 50:8-12.

FAO. 2004. Worldwide Regulation for mycotoxins in food and feed in 2003. FAO Food and Nutrition Paper 81. Rome (Italy): FAO.

Fardiaz S. 1996. Mycotoxin contamination of grains-a review of research in Indonesia. In: Highley E, Johnson GI, editors. 17th ASEAN Technical Seminar on Grain Postharvest Technology. Lumut, 25-17 July 1995. Canberra (AUS): Australian Centre for International Agricultural Research.

Ginting NG. 1984. Aflatoksin pada pakan ayam pedaging di Daerah Khusus Ibukota Jakarta Raya dan Kotamadya Pontianak. Penyakit Hewan. 16:212-214.

Gowda NKS, Swamy HVLN, Mahajan P. 2013. Recent advances for control, counteraction and amelioration of potential aflatoxins in animal feeds. In: Razzaghi-Abyaneh M, editor. Aflatoxins-Recent Advances and Future Prospects. Rijeka (Croatia): InTech.

Groopman JD, Kensler TW, Wild CP. 2008. Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries. Annu Rev Public Health. 29:187-203.

Hagler WM, Towers JNR, Mirocha CJ, Eppley RM, Bryden WL. 2001. Zearalenone: mycotoxin or mycoestrogen? In: Summerell, Leslie JF, Backhouse D, Bryden WL, Burgess LW, editors. Fusarium Paul E Nelson Meml Symp. Saint Paul (US): APS Press. p. 321-331.

Jones FT, Genter MB, Hagler WM, Hansen JA, Mowrewy BA, Poore MH, Whitlow LW. 1994. Understanding and coping with effects of mycotoxins in livestock feed and forage. Raleigh (US): North Carolina State University.

Khotimah K, Indrawati A, Latif H. 2015. Identification of fungi and mycotoxin in layer feed sold in traditional markets of Bogor, Indonesia. Int J Curr Res Biosci Plant Biol. 2:97-104.

Kuiper-Goodman T. 2004. Risk assessment and risk management of mycotoxins in food. In: Magan N, Olsen M, editors. Mycotoxins in Food. Cambridge (UK): Woodhead Publishing.

Kurtz HJ, Mirocha J. 1978. Zearalenone (F2) induced estrogenic syndrome in swine. In: Wyllie TD, Morehouse LG, editors. Mycotoxic fungi, mycotoxins, mycotoxicoses. Vol 2. New York (US): Marcel Dekker. p. 1256-1264.

Lopez-Garcia R, Park DL. 1998. Effectiveness of post-harvest procedures in management mycotoxin hazars. In: Bhatnagar D, Sinha S, editors. Mycotoxins in agriculture and food safety. New York (US): Marcel Dekker. p. 407-433.

Magnoli C, Dalcero AM, Chiacchiera SM, Miazzo R, Saenz MA. 1998. Enumeration and identification of Aspergillus group and Penicillium species in poultry feeds from Argentina. Mycopathologia. 142:27-32.

Martindah E, Maryam R, Wahyuwardani S, Widiyanti PM. 2015. Studi pendahuluan epidemiologi kontaminasi aflatoksin B1 pada pakan ayam. Dalam: Noor SM, Handiwirawan E, Martindah E, Widiastuti R, Sianturi RSG, Herawati T, Purba M, Anggraeny YN, Batubara A, penyunting. Teknologi Peternakan dan Veteriner untuk Peningkatan Daya Saing dan Mewujudkan Kedaulatan Pangan Hewani. Prosiding Seminar Nasional Teknologi Peternakan dan Veteriner. Jakarta, 8-9 Oktober 2015. Jakarta (Indonesia): Puslitbangnak. hlm. 525-531.

Maryam R. 2006. Pengendalian terpadu kontaminasi mikotoksin. Wartazoa. 16:21-30.

Moore DD, Chin LJ, Bryden WL. 2008. Contamination of Australian animal feedstuff and forages with mycotoxins. Proc Aust Soc Anim Prod. 27:35.

Nelson PE, Desjardins AE, Plattner RD. 1993. Fumonisins, mycotoxins produced by Fusarium species: Biology, chemistry and significance. Annu Rev Phytopathol. 31:233-252.

Nizamlýolu F, Oguz H. 2003. Occurrence of aflatoxins in layer feed and corn samples in Konya Province, Turkey. Food Addit Contam. 20:654-658.

Peraica M, Radić B, Lucić A, Pavlović M. 1999. Toxic effects of mycotoxins in humans. Bull World Health Organ. 77:754-766.

Reddy KRN, Abbas HK, Abel CA, Shier WT, Oliveira CAF, Raghavender CR. 2009. Mycotoxin contamination of commercially important agricultural commodities. Toxin Rev. 28:154-168.

Retnani Y, Putra ED, Herawati L. 2011. The effect of different water spraying level and stroge periode on endurance of pellet broiler finisher. Agripet. 11:10-14.

Rocha F, Duarte KMR, Gomes LH, Mattos WT, Lira SP, Alcantara PB. 2014. Introduction of the neMDH gene in Urochloa brizantha for aluminium tolerance in agronomic assays. Greener J Agric Sci. 4:110-116.

Rodrigues I, Naehrer K. 2012. Prevalence of mycotoxins in feedstuffs and feed surveyed worldwide in 2009 and 2010. Phytopathol Mediterr. 51:175-192.

Schatzmayr G, Streit E. 2013. Global occurrence of mycotoxins in the food and feed chain: Facts and figures. World Mycotoxin J. 6:213-222.

Schiefer HB. 1990. Mycotoxins in indoor air: A critical toxicological viewpoint. In: Indoor air '90: Proceedings of the 5th International Conference on Indoor Air Quality and Climate. Toronto, 29 July-3 August 1990. Toronto (Canada): International Conference on Indoor Air Quality and Climate. p. 167-72.

Scholl PF, Groopman JD. 2008. Long-term stability of human aflatoxin B1 albumin adducts assessed by isotope dilution mass spectrometry and highperformance liquid chromatographye fluorescence. Cancer Epidemiol Biomarkers Prev. 17:1436-1439.

Skrbi B, Zivancev J, Antic I, Godula M. 2014. Levels of aflatoxin M1 in different types of milk collected in Serbia: Assessment of human and animal exposure. Food Control. 40:113-119.

SNI. 2001. Batas maksimum cemaran mikroba dan batas maksimum residu dalam bahan makanan asal hewan. Jakarta (Indonesia): Standar Nasional Indonesia.

SNI. 2009a. SNI 3148.3:2009. Pakan konsentrat-Bagian 3: Ayam ras petelur (layer concentrate). Jakarta (Indonesia): Standar Nasional Indonesia.

SNI. 2009b. SNI 3148.5:2009. Pakan konsentrat-Bagian 5: Ayam ras pedaging (broiler concentrate). Jakarta (Indonesia): Standar Nasional Indonesia.

Swamy HVLN. 2009. Mycotoxins-Part 2. Current thoughts on global mycotoxicoses. World Poult. 25:18-20.

Tangendjaja B, Rahmawati S, Wina E. 2008. Mycotoxin contamination on corn used by feed mills in Indonesia. Indonesia J Agric Sci. 9:68-76.

Thirumala-Devi K, Mayo M a, Reddy G, Reddy DVR. 2002. Occurrence of aflatoxins and ochratoxin A in Indian poultry feeds. J Food Prot. 65:1338-1340.

Tsakiris IN, Tzatzarakis MN, Alegakis AK, Vlachou MI, Renieri EA, Tsatsakis AM. 2013. Risk assessment scenarios of children’s exposure to aflatoxin M1 residues in different milk types from the Greek market. Food Chem Toxicol. 56:261-265.

van de Venter T. 2000. Emerging food-borne diseases: A global responsibility. Food Nutr Agric. 26:4-13.

Wacoo AP, Wendiro D, Vuzi PC, Hawumba JF. 2014. Methods for detection of aflatoxins in agricultural food crops. J Appl Chem. 2014:1-15.

WHO. 1978. Selected mycotoxins: Ochratoxins, trichothecenes, ergot (environmental health criteria 105). Geneva (Switzerland): World Health Organization.

Wild CP. 2007. Aflatoxin exposure in developing countries: The critical interface of agriculture and health. Food Nutr Bull. 28.

Wild CP, Gong YY. 2009. Mycotoxins and human disease: A largely ignored global health issue. Carcinogenesis. 31:71-82.

Zain ME. 2011. Impact of mycotoxins on humans and animals. J Saudi Chem Soc. 15:129-144.

Zinedine A, Juan C, Soriano JM, Moltó JC, Idrissi L, Mañes J. 2007. Limited survey for the occurrence of aflatoxins in cereals and poultry feeds from Rabat, Morocco. Int J Food Microbiol. 115:124-127.

Zinedine A, Mañes J. 2009. Occurrence and legislation of mycotoxins in food and feed from Morocco. Food Control. 20:334-344.

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